Enhanced Sensitive Love Wave Surface Acoustic Wave Sensor Designed for Immunoassay Formats
نویسندگان
چکیده
We report a Love wave surface acoustic wave (LW-SAW) immunosensor designed for the detection of high molecular weight targets in liquid samples, amenable also for low molecular targets in surface competition assays. We implemented a label-free interaction protocol similar to other surface plasmon resonance bioassays having the advantage of requiring reduced time analysis. The fabricated LW-SAW sensor supports the detection of the target in the nanomolar range, and can be ultimately incorporated in portable devices, suitable for point-of-care testing (POCT) applications.
منابع مشابه
TiO2 based surface acoustic wave gas sensor with modified electrode dimensions for enhanced H2 sensing application
The design and optimization of nanostructure-based surface acoustic wave (SAW) gas sensor is analyzed based on TiO2 sensing layer and modified electrode dimensions. The sensitivity of the gas sensor depends upon the type of sensing layer used and active surface area obtained by varying the aspect ratio. The performance of the sensor is observed from 0.1ppm to 100ppm concentration of ...
متن کاملEnhanced Sensitivity of Wireless Chemical Sensor Based on Love Wave Mode
A 440MHz wireless and passive Love-wave-based chemical sensor was developed for CO2 detection. The developed device was composed of a reflective delay line patterned on 41 YX LiNbO3 piezoelectric substrate, a poly(methyl methacrylate) (PMMA) waveguide layer, and Teflon AF 2400 sensitive film. A theoretical model is presented to describe wave propagation in Love wave devices with large piezoelec...
متن کاملWireless and Simultaneous Detections of Multiple Bio-Molecules in a Single Sensor Using Love Wave Biosensor
A Love wave-based biosensor with a 440 MHz center frequency was developed for the simultaneous detection of two different analytes of Cartilage Oligomeric Matrix Protein (COMP) and rabbit immunoglobulin G (IgG) in a single sensor. The developed biosensor consists of one-port surface acoustic wave (SAW) reflective delay lines on a 41° YX LiNbO3 piezoelectric substrate, a poly(methyl methacrylate...
متن کاملReal Time Cascade Impactor Based On Surface Acoustic Wave Delay Lines for PM10 and PM2.5 Mass Concentration Measurement
In this research, Surface Acoustic Wave (SAW) sensors are combined with a cascade impactor to perform real time PM10 and PM2.5 mass concentration measurements. The SAW sensors consist of 125 MHz delay lines based on Love waves propagating on an AT-cut quartz substrate. The Love waves are guided on the substrate's surface using a silica layer. SAW sensors themselves are not capable to discrimina...
متن کاملA Theoretical Study of Love Wave Sensors Based on ZnO–Glass Layered Structures for Application to Liquid Environments
The propagation of surface acoustic Love modes along ZnO/glass-based structures was modeled and analysed with the goal of designing a sensor able to detect changes in the environmental parameters, such as liquid viscosity changes and minute amounts of mass supported in the viscous liquid medium. Love mode propagation was modeled by numerically solving the system of coupled electro-mechanical fi...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره 15 شماره
صفحات -
تاریخ انتشار 2015